Multiple personalities of neuregulin gene family members
نویسندگان
چکیده
منابع مشابه
DISC1: A Schizophrenia Gene with Multiple Personalities
Two papers address the contribution of DISC1 to neural development and schizophrenia risk in this issue of Neuron. These complementary studies elegantly bridge the gap between genetic and cellular studies of schizophrenia, providing a level of functional validation that is often lacking in the field.
متن کامل1,4-Dihydropyridines: The Multiple Personalities of a Blockbuster Drug Family
More than 40 years after their introduction in therapy, 1,4-dihydropyridines (DHPs) are still amongst the most prescribed drugs in the world. Though they all share a similar mechanism of action blocking L-type voltage-gated Ca(2+) channels, DHPs differ in crucial pharmacological properties like tissue selectivity and cardiodepressant activity. This review examines how changes in the DHP structu...
متن کاملThe multiple personalities of Alix
Introduction Proteins that can regulate seemingly disparate mechanisms do so by engaging in multiple distinct protein interaction networks. Such multifunctional activities are characteristic of a protein in mammalian cells known as 'Alix' or 'AIP1'. Both names derive from its original discovery as an interaction partner of ALG-2, a Ca 2+-binding protein implicated in apoptotic signaling (Missot...
متن کاملThe multiple personalities of Alix.
Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its association with pro-apoptotic signaling. More recent evidence has established that Alix has a hand in regulating other cellular mechanisms, including endocytic membrane trafficking and cell adhesion. Although Alix appears to participate directly in these various activities, the role it plays in ea...
متن کاملDistinct Functions of Egr Gene Family Members in Cognitive Processes
The different gene members of the Egr family of transcriptional regulators have often been considered to have related functions in brain, based on their co-expression in many cell-types and structures, the relatively high homology of the translated proteins and their ability to bind to the same consensus DNA binding sequence. Recent research, however, suggest this might not be the case. In this...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Comparative Neurology
سال: 2004
ISSN: 0021-9967,1096-9861
DOI: 10.1002/cne.20091